×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400
AlteredExpression
group
LHGDN
However, nuclear beta-catenin expression was significantly greater in MCRA patients' tumours than in sporadic adenomas .
17505512 2007
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
GeneticVariation
group
LHGDN
Clinical features of familial adenomas polyps in Chinese and establishment of its immortal lymphocyte cell lines.
17569124 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400
GeneticVariation
group
LHGDN
Of MPs and SA s, 72% had either BRAF or KRAS mutation.
16879389 2006
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
AlteredExpression
group
LHGDN
Complete loss of APC protein did not influence morphology, location, or appearance of adenomas , nor was it affected by the patient's age.
16804979 2006
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400
GeneticVariation
group
LHGDN
In study II, archived stool samples from patients with advanced adenomas containing known KRAS mutations were assayed, along with controls.
19026650 2009
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400
Biomarker
group
LHGDN
These results suggest that Survivin and p53 may play important roles in the transition from IPMT Adenoma to IPMT CIS.
12794243 2002
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400
GeneticVariation
group
LHGDN
Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype.
17374954 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400
Biomarker
group
LHGDN
[Expressions of beta-catenin, p53 and proliferating cell nuclear antigen in the carcinogenesis of colorectal adenoma].
12515622 2002
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
GeneticVariation
group
LHGDN
Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas.
18199528 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400
Biomarker
group
LHGDN
KRAS transitions and villous growth in colorectal adenomas.
16373972 2005
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
Biomarker
group
LHGDN
We analyzed the phenotypes, DNA ploidy patterns, and microsatellite regions linked to adenomatous polyposis coli (APC ) gene on chromosome 5q of low-grade gastric adenomas /dysplasias, Vienna Category 3, to investigate whether these lesions have the potential to become adenocarcinomas.
17964080 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400
GeneticVariation
group
LHGDN
Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.
16896030 2006
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
GeneticVariation
group
LHGDN
CTNNB1 mutations were found in 2/19 adenomas without APC mutation.
12737446 2003
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
AlteredExpression
group
LHGDN
Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.
18403596 2008
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400
Biomarker
group
LHGDN
[Expressions of beta-catenin, p53 and proliferating cell nuclear antigen in the carcinogenesis of colorectal adenoma].
12515622 2002
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400
Biomarker
group
LHGDN
P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia.
12297840 2002
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400
GeneticVariation
group
LHGDN
CTNNB1 mutations were found in 2/19 adenomas without APC mutation.12737446 2003
×
Entrez Id: 324
Gene Symbol: APC
APC
0.400
GeneticVariation
group
LHGDN
No mutations of beta-catenin were found in adenocarcinomas, or adenomas /dysplasia without APC mutation.
12163385 2002
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400
Biomarker
group
LHGDN
In conclusion, both bcl-2 and p53 immunohistochemical profiles may be useful adjuncts in detecting adenomas with a malignant potential, whereas bcl-2 could be used in combination with Dukes' stage as a predictor of prognosis in colorectal cancer.
17562177 2008
×
Entrez Id: 23600
Gene Symbol: AMACR
AMACR
0.360
GeneticVariation
group
LHGDN
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
17684125 2007
×
Entrez Id: 23600
Gene Symbol: AMACR
AMACR
0.360
Biomarker
group
LHGDN
Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma .16424894 2006
×
Entrez Id: 6414
Gene Symbol: SELENOP
SELENOP
0.330
GeneticVariation
group
LHGDN
Three SNPs located in the 3' region of SEPP1 , which is overlapping with the promoter region of an antisense transcript, were significantly associated with adenoma risk: homozygotes at two SEPP1 loci (31,174 bp 3' of STP A>G and 43,881 bp 3' of STP G>A) were associated with increased adenoma risk [odds ratio (OR), 1.48; 95% confidence interval (95% CI), 1.00-2.19 and OR, 1.53; 95% CI, 1.05-2.22, respectively] and the variant SEPP1 44,321 bp 3' of STP C>T was associated with a reduced adenoma risk (CT versus CC OR, 0.85; 95% CI, 0.63-1.15).
18483336 2008
×
Entrez Id: 7296
Gene Symbol: TXNRD1
TXNRD1
0.310
GeneticVariation
group
LHGDN
Consistent with the individual SNP results, we observed a significant overall association with adenoma risk for SEPP1 and TXNRD1 (global P = 0.02 and 0.008, respectively) but not for the four GPX genes.
18483336 2008
×
Entrez Id: 54822
Gene Symbol: TRPM7
TRPM7
0.310
GeneticVariation
group
LHGDN
The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk.
17823441 2007
×
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
0.100
Biomarker
group
LHGDN
None of the 141 normal-population adenoma patients carried biallelic germline MYH variants (95% CI = 0.06-4.1%) and 3 were heterozygotes (2.1%).
14999774 2004